How do habits influence lifespan? In a study monitoring the lives of African turquoise killifish, NOMIS Awardees Anne Brunet and Karl Deisseroth and colleagues at Stanford University have found that […]
What makes a crisis feel “normal”? How can identical twins have completely different health journeys? For innovative work that addresses these questions through cross-field collaboration, Rachit Dubey and Jiacheng Miao […]
NOMIS Center for Immunobiology and Microbial Pathogenesis Director Susan Kaech and NOMIS researchers Nicholas Christakis and Joanna Wysocka have been elected to the US National Academy of Sciences. They are among 120 […]
Abstract: Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behavioral tracking of the […]
Abstract: Polyglutamine (polyQ) expansion is associated with pathogenic protein aggregation in neurodegenerative disorders. However, long polyQ tracts are also found in many transcription factors (TFs), such as FOXP2, a TF implicated […]
Abstract: Genome-wide association studies (GWAS) identified thousands of genetic variants linked to phenotypic traits and disease risk. However, mechanistic understanding of how GWAS variants influence complex morphological traits and can, in […]
Abstract: Transcription factors (TFs) can define distinct cellular identities despite nearly identical DNA-binding specificities. One mechanism for achieving regulatory specificity is DNA-guided TF cooperativity. Although in vitro studies suggest that it may be common, […]
