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King’s College London

Research is core to King’s, what we do, what we care about and how we educate. It is how we channel our creativity to further knowledge and understanding, challenge convention and deliver impact.

Our vision is to deliver research to inform and innovate. By providing the best environment, support and networks for our community, from postgraduate research students to senior academics, we will deliver research excellence.

Launched in December 2016, King’s Research Strategy sets out our vision to better enable informative and innovative research.

By delivering world-leading and outward-looking research focused on meeting societal need, King’s will make the world a better place. We have focused our efforts around five pillars:

Retaining, developing and recruiting world-class talent
Providing the best environment and systems to deliver world-leading research
Broadening the research base whilst increasing quality
Increasing impact and expanding research partnerships
Delivering research-enhanced education

Reader in RNA biology and molecular neurodegeneration
King’s College London
September 4, 2023
NOMIS researcher Marc-David Ruepp and colleagues have discovered a mechanism of RBM39 autoregulation, providing a solid basis to design alternative anti-cancer therapies. Their findings were published in Nature. RBM39 is […]
July 13, 2021
NOMIS researcher Marc-David Ruepp and colleagues have determined the different protein and RNA interactomes of soluble and phase-separated FUS. Their research was published in Nucleic Acids Research on July 7. […]
January 22, 2021
Jonas Mechtersheimer and Daniel Jutzi, students in the research laboratory of NOMIS scientist Marc-David Ruepp, obtained their PhDs in molecular biology on May 1, 2020, and September 1, 2020, respectively, […]
July 21, 2021
Abstract: Liquid–liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving force underlying the formation of membrane-less organelles. Such biomolecular condensates have various biological functions and have been […]
January 1, 2021
Abstract: Mutations in fused in sarcoma (FUS) lead to amyotrophic lateral sclerosis (ALS) with varying ages of onset, progression and severity. This suggests that unknown genetic factors contribute to disease pathogenesis. […]
January 1, 2021
Abstract: RNA-binding proteins (RBPs) are emerging as important effectors of the cellular DNA damage response (DDR). The RBP FUS is implicated in RNA metabolism and DNA repair, and it undergoes reversible […]
March 1, 2018
Abstract: Pre-mRNA splicing is an essential step in eukaryotic gene expression. Mutations in cis-acting sequence elements within pre-mRNA molecules or trans-acting factors involved in pre-mRNA processing have both been linked to […]
January 15, 2018
Abstract: CRISPR/Cas9-based genome editing offers the possibility to knock out almost any gene of interest in an affordable and simple manner. The most common strategy is the introduction of a frameshift […]
June 1, 2017
Abstract: Crystal structures can identify ligand-receptor interactions and assist the development of novel therapeutics, but experimental challenges sometimes necessitate the use of homologous proteins. Tropisetron is an orthosteric ligand at both […]
April 1, 2017
Abstract: Epibatidine is an alkaloid toxin that binds with high affinity to nicotinic and muscarinic acetylcholine receptors, and has been extensively used as a research tool. To examine binding interactions at […]
July 15, 2016
Abstract: Fused in sarcoma (FUS) is a ubiquitously expressed RNA-binding protein proposed to function in various RNA metabolic pathways, including transcription regulation, pre-mRNA splicing, RNA transport and microRNA processing. Mutations in […]
January 1, 2015
Abstract: The pharmacological characterization of ligands depends upon the ability to accurately measure their binding properties. Fluorescence provides an alternative to more traditional approaches such as radioligand binding. Here we describe […]
March 1, 2014
Abstract: Background Spinal muscular atrophy (SMA) is a fatal motor neuron disease of childhood that is caused by mutations in the SMN1 gene. Currently, no effective treatment is available. One possible […]