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Max Planck Institute of Molecular Cell Biology and Genetics

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We do pioneering basic research. 500 curiosity-driven scientists from over 50 countries ask: How do cells form tissues? Our research programs span multiple scales of magnitude, from molecular assemblies to organelles, cells, tissues, organs, and organisms.

Anthony Hyman
Group leader and a director of the Max Planck Institute of Molecular Cell Biology and Genetics
Max Planck Institute of Molecular Cell Biology and Genetics
July 11, 2022
New structure found in cells
NOMIS Awardee Anthony Hyman and colleague Rohit Pappu and colleagues have discovered that clusters of proteins can form in solutions with concentrations that are well below the threshold for phase […]
June 30, 2022
Anthony Hyman awarded 2022 Körber European Science Prize
NOMIS Awardee Anthony Hyman has been awarded the 2022 Körber European Science Prize for the discovery of condensates—cell droplets without a membrane. In 2009, Hyman and his team – during […]
November 8, 2021
NOMIS Award presented to four pioneering scientists
Recognizing their outstanding contributions to the advancement of science and human progress through their pioneering, collaborative research, the 2021 as well as the 2020 NOMIS Distinguished Scientist and Scholar Award […]
April 27, 2020
NOMIS Awardee Anthony Hyman named member of National Academy of Sciences
National Academy of Sciences Elects New Members WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 26 international members in recognition of their distinguished […]
April 14, 2020
NOMIS announces recipients of 2020 Distinguished Scientist and Scholar Award
The NOMIS Foundation is delighted to announce two new recipients of the fifth annual NOMIS Distinguished Scientist and Scholar Award — congratulations to Ronald M. Evans of the Salk Institute […]
July 12, 2022
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions
Abstract: Macromolecular phase separation is thought to be one of the processes that drives the formation of membraneless biomolecular condensates in cells. The dynamics of phase separation are thought to follow […]
March 1, 2022
Sequence-dependent surface condensation of a pioneer transcription factor on DNA
Abstract: Biomolecular condensates are dense assemblies of proteins that form distinct biochemical compartments without being surrounded by a membrane. Some, such as P granules and stress granules, behave as droplets and […]
November 2, 2021
Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils
Abstract: Glycine-rich regions feature prominently in intrinsically disordered regions (IDRs) of proteins that drive phase separation and the regulated formation of membraneless biomolecular condensates. Interestingly, the Gly-rich IDRs seldom feature poly-Gly […]
March 1, 2021
Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
Abstract: Biomolecular condensates are membraneless intracellular assemblies that often form via liquid−liquid phase separation and have the ability to concentrate biopolymers. Research over the past 10 years has revealed that condensates […]
December 1, 2020
Drops and fibers - How biomolecular condensates and cytoskeletal filaments influence each other
Abstract: The cellular cytoskeleton self-organizes by specific monomer-monomer interactions resulting in the polymerization of filaments. While we have long thought about the role of polymerization in cytoskeleton formation, we have only […]
December 1, 2018
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation
Abstract: Amyotrophic lateral sclerosis (ALS) is the most frequent motor neuron disease. Cytoplasmic fused in sarcoma (FUS) aggregates are pathological hallmarks of FUS-ALS. Proper shuttling between the nucleus and cytoplasm is […]
February 13, 2018
Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy
Abstract: Perturbations in stress granule (SG) dynamics may be at the core of amyotrophic lateral sclerosis (ALS). Since SGs are membraneless compartments, modeling their dynamics in human motor neurons has been […]
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions
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New structure found in cells
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Anthony Hyman awarded 2022 Körber European Science Prize
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