Columbia Zuckerman Institute

The Zuckerman Institute brings together an extraordinary group of researchers from across Columbia University, in a state-of-the-art facility, to transform our understanding of the brain and mind.

Franck Polleux

Professor of neuroscience and a member of the Mortimer B. Zuckerman Mind Brain Behavior Institute

James P. Noonan

Albert E. Kent Professor of Genetics and Professor of Neuroscience

Columbia Zuckerman Institute, Yale University

March 17, 2025

First-ever imaging of changes in synaptic connections during memory formation

NOMIS researcher Franck Polleux and fellow scientists at Columbia’s Zuckerman Institute have, for the first time, observed how synaptic connections in the brain change during memory formation in living mice. […]

February 16, 2023

Developmental mechanisms underlying the evolution of human cortical circuits

In Nature Reviews Neuroscience, NOMIS researcher Franck Polleux and Pierre Vanderhaeghen discuss the genomic modifications and changes in neurodevelopmental mechanisms that underpin the human brain’s unique complexity and function. Abstract […]

February 10, 2025

Visually guided in vivo single-cell electroporation for monitoring and manipulating mammalian hippocampal neurons

Abstract: Sparse, single-cell labeling approaches enable high-resolution, high signal-to-noise recordings from subcellular compartments and intracellular organelles and allow precise manipulations of individual cells and local circuits while minimizing complex changes associated […]

December 18, 2024

Synaptic basis of feature selectivity in hippocampal neurons

Abstract: A central question in neuroscience is how synaptic plasticity shapes the feature selectivity of neurons in behaving animals1. Hippocampal CA1 pyramidal neurons display one of the most striking forms of […]

October 1, 2024

If you please, draw me a neuron — linking evolutionary tinkering with human neuron evolution

Abstract: Animal speciation often involves novel behavioral features that rely on nervous system evolution. Human-specific brain features have been proposed to underlie specialized cognitive functions and to be linked, at least […]

First-ever imaging of changes in synaptic connections during memory formation

News

Visually guided in vivo single-cell electroporation for monitoring and manipulating mammalian hippocampal neurons

Insight

Synaptic basis of feature selectivity in hippocampal neurons

Insight