Cerebrospinal fluid CSF contains a tightly regulated immune system However knowledge is lacking about how CSF immunity is altered with aging or neurodegenerative disease Here we performed single cell RNA sequencing hellip

Background Cerebrospinal fluid CSF provides basic mechanical and immunological protection to the brain Historically analysis of CSF has focused on protein changes yet recent studies have shed light on cellular hellip

Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain ageing1 3 Cerebrospinal fluid CSF makes up the immediate environment hellip

Cerebrospinal fluid CSF proteins and their structures have been implicated in aging and neurodegenerative diseases In the present study we used limited proteolysis mass spectrometry LiP MS to screen for new aging associated hellip

The human brain vasculature is of great medical importance its dysfunction causes disability and death1 and the specialized structure it forms the blood brain barrier impedes the treatment of nearly all brain disorders2 3 hellip

The ability to slow or reverse biological ageing would have major implications for mitigating disease risk and maintaining vitality1 Although an increasing number of interventions show promise for rejuvenation2 their hellip

Physical exercise is generally beneficial to all aspects of human and animal health slowing cognitive ageing and neurodegeneration1 The cognitive benefits of physical exercise are tied to an increased plasticity hellip

Alzheimer s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function1 However little is known about the contribution of the adaptive immune response in Alzheimer s disease2 Here hellip

Recent studies indicate that the adaptive immune system plays a role in Lewy body dementia LBD However the mechanism regulating T cell brain homing in LBD is unknown Here we hellip

Although SARS CoV 2 primarily targets the respiratory system patients with and survivors of COVID 19 can suffer neurological symptoms1 3 However an unbiased understanding of the cellular and molecular processes that are affected hellip

Neurofilament light chain NfL has emerged as a promising blood biomarker for the progression of various neurological diseases NfL is a structural protein of nerve cells and elevated NfL levels hellip

Organismal aging is often characterized as a steady monotonic decline of organ and tissue function However recent studies indicate spatial and temporal variations of aging rates across the lifespan We hellip

We previously identified 529 proteins that had been reported by multiple different studies to change their expression level with age in human plasma In the present study we measured the hellip

Ageing is the single greatest cause of disease and death worldwide and understanding the associated processes could vastly improve quality of life Although major categories of ageing damage have been hellip

The vascular interface of the brain known as the blood brain barrier BBB is understood to maintain brain function in part via its low transcellular permeability1 2 3 Yet recent studies have demonstrated hellip

The development of clinical interventions that significantly improve human healthspan requires robust markers of biological age as well as thoughtful therapeutic targets To promote these goals we performed a systematic hellip

A rapidly ageing population and a limited therapeutic toolbox urgently necessitate new approaches to treat neurodegenerative diseases Brain ageing the key risk factor for neurodegeneration involves complex cellular and molecular hellip

Microglia become progressively activated and seemingly dysfunctional with age and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases Here we report a hellip

Aging is a predominant risk factor for several chronic diseases that limit healthspan1 Mechanisms of aging are thus increasingly recognized as potential therapeutic targets Blood from young mice reverses aspects hellip

An aged circulatory environment can activate microglia reduce neural precursor cell activity and impair cognition in mice We hypothesized that brain endothelial cells BECs mediate at least some of these hellip

Microglia maintain homeostasis in the central nervous system through phagocytic clearance of protein aggregates and cellular debris This function deteriorates during ageing and neurodegenerative disease concomitant with cognitive decline However hellip

Microglia are increasingly recognized for their major contributions during brain development and neurodegenerative disease It is currently unknown whether these functions are carried out by subsets of microglia during different hellip

Motivation Multiple biological clocks govern a healthy pregnancy These biological mechanisms produce immunologic metabolomic proteomic genomic and microbiomic adaptations during the course of pregnancy Modeling the chronology of these adaptations hellip

Here we present a compendium of single cell transcriptomic data from the model organism Mus musculus that comprises more than 100 000 cells from 20 organs and tissues These data represent a hellip

Bioorthogonal tools enable cell type specific proteomics a prerequisite to understanding biological processes in multicellular organisms Here we report two engineered aminoacyl tRNA synthetases for mammalian bioorthogonal labeling a tyrosyl ScTyrY43G and a hellip