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Brain Rejuvenation Factors From Blood

NOMIS Project 2017

— 2022

Brain aging results in cognitive decline and is the major cause of neurodegenerative diseases including Alzheimer’s, Parkinson’s, vascular dementia and stroke. My research team discovered that circulatory factors in blood from young mice or humans are capable of reversing aspects of brain aging in aged mice at the molecular, cellular, physiological and functional level. These seminal discoveries, which are being commercialized and tested in a number of phase 2 clinical trials, opened a fascinating series of questions we are currently pursuing in our project, Brain Rejuvenation Factors From Blood ― e.g., What is the identity of blood-borne rejuvenating factors? Where do they come from? How do they enter the brain and communicate with it? What is the genetic basis of brain rejuvenation? How does the brain age in the first place? We are studying these questions by employing a combination of genetic, cell biology, and -omics approaches in killifish, mice and humans, and through the development of bioorthogonal tools for the in vivo labeling of proteins. The potential to tackle and answer these questions promises to usher in a new era in aging and dementia research, which may “disrupt” our approach to treating neurodegenerative diseases.


NOMIS Researcher(s)


Project News

A new study by scientist David Gate, NOMIS Awardee Tony Wyss-Coray and their colleagues has found that cerebrospinal fluid, the brain’s immune system, becomes dysregulated as we age and plays […]

NOMIS Awardee Tony Wyss-Coray and colleagues have discovered that cerebrospinal fluid (CSF) from young mice can improve memory function in older mice. Their work was published in Nature on May […]

NOMIS Distinguished Scientist Tony Wyss-Coray appeared on the Swiss television program, Einstein, which aired on Feb. 15, 2018. The story, “Kampf gegen das Vergessen” (“The fight against forgetting”), addresses the crippling effects […]

Swiss newspaper Neue Zürcher Zeitung (NZZ) has published an article about the groundbreaking research of NOMIS Distinguished Scientist Tony Wyss-Coray, professor of neurology and neurological sciences at Stanford University. Wyss-Coray’s research has shown […]

Karl Deisseroth, Tony Wyss-Coray and Svante Pääbo Recognizing not only scientific excellence, but also celebrating researchers who push for unconventional paths and show exceptional engagement in insight-driven research and collaboration, […]

NOMIS Distinguished Scientist Award 2017

The Swiss newspaper, Tages-Anzeiger, has published an article about the work of NOMIS Distinguished Scientist and Scholar Award winner Tony Wyss-Coray. The article, published in German (“Der Verjüngungsforscher”), discusses Wyss-Coray’s […]


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