is our passion
Home / Projects / Determining Biological Age in Humans

Determining Biological Age in Humans

NOMIS Project 2016

— 2023

Researchers at the Salk Institute have taken on the challenge of developing a scientific method that shows to what extent molecular events determine the rate of aging in humans, which differs significantly from individual to individual. This explains why a person’s chronological age is not the most useful predictor of health. Recent analyses based on morphological and physiological data have shown that “true” biological age can vary greatly between people of the same chronological age. However, none of these measurements explain why individuals age at a varied pace, nor do they provide insights into the underlying causes of aging.

The Determining Biological Age in Humans project aimed to develop an innovative scientific method that would determine biological age based on molecular and cellular criteria, and which would allow the study of the aging process in living cells in adults across different age groups. Such information could be used to devise personalized strategies (e.g., preventive interventions or changes in diet or exercise) to optimize organ performance in adults and to minimize age-related physiological decline.

The Determining Biological Age in Humans project was led by Martin Hetzer at the Salk Institute.


NOMIS Researcher(s)

Member of the NOMIS Foundation Board of Directors
Institute of Science and Technology Austria (ISTA), NOMIS Foundation

Project News


Project Insights

Abstract: During apoptosis, caspases degrade 8 out of ~30 nucleoporins to irreversibly demolish the nuclear pore complex. However, for poorly understood reasons, caspases are also activated during cell differentiation. Here, we show that sublethal activation of caspases during myogenesis results in the transient proteolysis of four peripheral Nups and one transmembrane
Abstract: The LINC complex tethers the cell nucleus to the cytoskeleton to regulate mechanical forces during cell migration, differentiation, and various diseases. The function of LINC complexes relies on the interaction between highly conserved SUN and KASH proteins that form higher-order assemblies capable of load bearing. These structural details have emerged