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The Science of Health: The Fundamental Mechanisms of Organ Communication

NOMIS Project 2020

— 2024

The human body is a complex ecosystem in which dysfunction in one organ can disrupt body-wide equilibriums necessary for maintaining health. Thus, we are studying the mechanisms of cooperativity between interconnected networks including the brain, endocrine glands, gut, liver, immune cells and the microbiome.

The Science of Health: The Fundamental Mechanisms of Organ Communication project focuses on a superfamily of nuclear hormone receptors (NRs) that are critically involved in establishing and maintaining vitality through the regulation of nutrient distribution, metabolism and changes in response to stress. NRs function as molecular sensors to maintain equilibrium through a series of genomic programs. By deconstructing these programs at the molecular genetic level, we hope to gain knowledge about the metabolic basis of organ communication.

Approaching this investigation from three angles, we will first examine therapeutics that mimic the effect of exercise on the body—called exercise mimetics—with the goal of preventing neurodegenerative diseases. We previously discovered the prominent exercise mimetic target, the nuclear receptor PPARδ, which we can control with an orally active drug (sometimes called exercise in a pill). We will examine the impact of this drug in neurons and assess the therapeutic potential in mouse models of neurologic disease.

Secondly, we will explore the communication between the gut microbiome and the liver, leading to metabolic disorders, inflammatory bowel disease, autism and Parkinson’s disease. Additionally, we will evaluate the protective effects of vitamin D against liver damage and whether increasing vitamin D levels can promote repair.

Lastly, we will investigate how gut health is maintained as well as the roles of gut-derived signals in coordinating whole-body homeostasis. The NR farnesoid X receptor (FXR), which was originally discovered in our lab, serves as a sensor for nutritional cues and is a master regulator of gut health. We will explore how stimulation of FXR locally in the gut acts “globally” on the liver and the immune system to manage diabetes and metabolic disease.

The Science of Health project is being led by Ronald M. Evans, professor and director of the Salk Institute for Biological Studies’ Gene Expression Laboratory and holder of the March of Dimes Chair in Molecular and Developmental Biology.


NOMIS Researcher(s)

Professor, director of Salk’s Gene Expression Laboratory and holder of the March of Dimes Chair in Molecular and Developmental Biology
Salk Institute for Biological Studies

Project News

NOMIS Awardee and Salk Professor Ronald Evans has been named the 2024 recipient of the Japan Prize in the field of Medical Science and Pharmaceutical Science. The Japan Prize Foundation awards […]

In an article published in Gastroenterology, NOMIS Awardee Ronald M. Evans and colleagues report that a protein known as estrogen-related receptor gamma (ERR ɣ) is critical for preventing pancreatic auto-digestion […]

Recognizing their outstanding contributions to the advancement of science and human progress through their pioneering, collaborative research, the 2021 as well as the 2020 NOMIS Distinguished Scientist and Scholar Award […]


Project Insights

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core genes involved in cell-specific function, here we uncover a druggable SE-mediated RNA-binding protein (RBP) cascade that supports PDAC growth through enhanced mRNA translation. This cascade is
Abstract: Molecular classification of gastric cancer (GC) identified a subgroup of patients showing chemoresistance and poor prognosis, termed SEM (Stem-like/Epithelial-to-mesenchymal transition/Mesenchymal) type in this study. Here, we show that SEM-type GC exhibits a distinct metabolic profile characterized by high glutaminase (GLS) levels. Unexpectedly, SEM-type GC cells are resistant to glutaminolysis inhibition.