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Publications in Magnetosomes by NOMIS researchers

NOMIS Researcher(s)

Published in

August 1, 2020

Magnetotactic bacteria (MTB) synthesize iron oxide (Fe3O4) nanoparticles (NPs), called magnetosomes, with large sizes leading to a ferrimagnetic behavior and a stable magnetic moment at physiological temperature, a chain structure that prevents NP aggregation and promotes uniform NP distribution, and a mineral core of magnetite/maghemite composition, which can be stabilized by an organic coating. Such properties can favor magnetosome administration to humans under certain optimized non-toxic conditions of fabrication. In this review, I describe the fabrication methods, physico-chemical properties, and the anti-tumor activity of different types of MTB/magnetosome preparations, highlighting the bio-compatibility and excellent anti-tumor activity of purified non-pyrogenic magnetosome minerals stabilized by a synthetic chemical compound.

Research field(s)
Natural Sciences, Chemistry, Medicinal & Biomolecular Chemistry

NOMIS Researcher(s)

February 18, 2020

We report the synthesis in large quantity of highly pure magnetosomes for medical applications. For that, magnetosomes are produced by MSR-1 Magnetospirillum gryphiswaldense magnetotactic bacteria using minimal growth media devoid of uncharacterized and toxic products prohibited by pharmaceutical regulation, i.e., yeast extract, heavy metals different from iron, and carcinogenic, mutagenic and reprotoxic agents. This method follows two steps, during which bacteria are first pre-amplified without producing magnetosomes and are then fed with an iron source to synthesize magnetosomes, yielding, after 50 h of growth, an equivalent OD565 of ~8 and 10 mg of magnetosomes in iron per liter of growth media. Compared with magnetosomes produced in non-minimal growth media, those particles have lower concentrations in metals other than iron. Very significant reduction or disappearance in magnetosome composition of zinc, manganese, barium, and aluminum are observed. This new synthesis method paves the way towards the production of magnetosomes for medical applications.

Research field(s)
Health Sciences, Biomedical Research, Microbiology