Histones Archives - The NOMIS Foundation

Chromosomes in the eukaryotic nucleus are highly compacted. However, for many functional processes, including transcription initiation, the pairwise motion of distal chromosomal elements such as enhancers and promoters is essential and necessitates dynamic fluidity. Here, we used a live-imaging assay to simultaneously measure the positions of pairs of enhancers and promoters and their transcriptional output while systematically varying the genomic separation between these two DNA loci. Our analysis reveals the coexistence of a compact globular organization and fast subdiffusive dynamics. These combined features cause an anomalous scaling of polymer relaxation times with genomic separation leading to long-ranged correlations. Thus, encounter times of DNA loci are much less dependent on genomic distance than predicted by existing polymer models, with potential consequences for eukaryotic gene expression. © 2023 American Association for the Advancement of Science. All rights reserved.

Does action play any crucial role in our perception of pictures? The standard literature on picture perception has never explicitly tackled this question. This is for a simple reason. After all, objects in a picture seem to be static objects of perception. Thus, it might sound extremely controversial to say that action is crucial in picture perception. Contrary to this general intuitive stance, this paper defends, for the first time, the apparently very controversial claim, never addressed in the literature, that some of the specific and essential relations between vision and action make action (and its motoric basis) crucial in order for us to enter pictorial experience. I first discuss two ways in which vision and action are deeply linked, by describing the famous notions of Vision-for-Action and Sensorimotor Understanding. Then, I describe the special role they play in generating ordinary pictorial experience and suggest that, when we cannot rely on them while in front of a picture, we lose pictorial experience. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.

Publications in Histones by NOMIS researchers

Stochastic motion and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome

Why the Pictorial Needs the Motoric