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Research is the vital expression of humankind’s most important qualities: curiosity and imagination.

Explorers, inventors, pioneers—dedicated researchers on the frontiers of science and the humanities.

Insight, when it comes, changes everything.

Publications

The NOMIS community of researchers and partners is instrumental in driving interdisciplinary collaboration, generating insights and ultimately advancing our understanding of the world. A key component of these efforts is knowledge sharing. Comprising a unique offering of engaging scientific lectures, insightful films about our awardees’ research, and a comprehensive publication database, NOMIS Insights are designed to facilitate the sharing of knowledge. They showcase the groundbreaking findings and innovative perspectives born from NOMIS-supported research endeavors, embodying our dedication to enabling scientific progress.

Our NOMIS Insight database provides a comprehensive source of all publications resulting from NOMIS-supported research projects.

Iron oxide nanoparticles for therapeutic applications

NOMIS Researcher(s)

Published in

January 1, 2020

In nanomedicine, iron oxide nanoparticles are at an advanced stage, being commercialized for cancer treatment and iron-deficiency anemia treatment. Their therapeutic efficacy comes from their ability to target a tissue, activate a drug, locally produce a temperature increase following (or not) the application of an external source of energy, modify genes or activate various biological materials, or replace diseased cells by stem cells. Owing to these various mechanisms of action, they can potentially be used for treating a whole range of different diseases, making them more appealing than conventional drugs that target a more limited number of indications.

Research field(s)
Natural Sciences, Chemistry, Medicinal & Biomolecular Chemistry

DOI
10.1016/j.drudis.2019.09.020

Nano-therapies for glioblastoma treatment

NOMIS Researcher(s)

Published in

January 1, 2020

Traditional anti-cancer treatments are inefficient against glioblastoma, which remains one of the deadliest and most aggressive cancers. Nano-drugs could help to improve this situation by enabling: (i) an increase of anti-glioblastoma multiforme (GBM) activity of chemo/gene therapeutic drugs, notably by an improved diffusion of these drugs through the blood brain barrier (BBB), (ii) the sensibilization of radio-resistant GBM tumor cells to radiotherapy, (iii) the removal by surgery of infiltrating GBM tumor cells, (iv) the restoration of an apoptotic mechanism of GBM cellular death, (v) the destruction of angiogenic blood vessels, (vi) the stimulation of anti-tumor immune cells, e.g., T cells, NK cells, and the neutralization of pro-tumoral immune cells, e.g., Treg cells, (vii) the local production of heat or radical oxygen species (ROS), and (viii) the controlled release/activation of anti-GBM drugs following the application of a stimulus. This review covers these different aspects.

Research field(s)
Health Sciences, Clinical Medicine, Oncology & Carcinogenesis

DOI
10.3390/cancers12010242

Supporting stakeholders to anticipate and respond to risks in a Mekong river water-energy-food nexus

NOMIS Researcher(s)

Published in

January 1, 2020

The water-energy-food nexus concept is criticized as not yet fit for deeply integrated and contested governance agendas. One problem is how to achieve equitable risk governance and management where there is low consensus on priorities, poor inclusion and coordination of risk assessment procedures, and a weak emphasis placed on cross-scale and sectoral interactions over time. Participatory system dynamics modeling processes and analyses are promising approaches for such challenges but are currently underutilized in nexus research and policy. This paper shares our experience implementing one such analysis in the Mekong river basin, a paradigmatic example for international nexus research. Our transdisciplinary research design combined participatory causal loop diagramming processes, scenario modeling, and a new resilience analysis method to identify and test anticipated water-energy-food risks in Kratie and Stung Treng provinces in northeastern Cambodia. Our process generated new understanding of potential cross-sectoral and cross-level risks from major hydropower development in the region. The results showed expected trade-offs between national level infrastructure programs and local level food security, but also some new insights into the effects local population increases may have on local food production and consumption even before hydropower developments are built. The analysis shows the benefit of evaluating risks in the nexus at different system levels and over time because of how system dynamics and inflection points are taken into account. Additionally, our case illustrates the contribution participatory system-thinking processes can make to risk assessment procedures for complex systems transitions. We originally anticipated that any new capacity reported by partners and participants would come from our modeling results produced at the end of the process. However, participants in the modeling procedures also found the experience powerful the information sharing, rapid risk assessment, and personal learning it enabled. A lesson from our experience reinforces a message from the transdisciplinary research field that has not yet been absorbed into the nexus research and policy field wholeheartedly: we do not have to wait for perfect data and incontestable results before making a positive contribution to anticipating and responding to risks that emerge from nexus relations if we apply participatory and systems-thinking informed approaches.

Research field(s)
Natural Sciences, Biology, Ecology

DOI
10.5751/ES-11919-250429

Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3

NOMIS Researcher(s)

Published in

January 1, 2020

Repeat expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Expanded sense and antisense repeat RNA transcripts in C9orf72 are translated into five dipeptide-repeat proteins (DPRs) in an AUG-independent manner. We previously identified the heterogeneous ribonucleoprotein (hnRNP) A3 as an interactor of the sense repeat RNA that reduces its translation into DPRs. Furthermore, we found that hnRNPA3 is depleted from the nucleus and partially mislocalized to cytoplasmic poly-GA inclusions in C9orf72 patients, suggesting that poly-GA sequesters hnRNPA3 within the cytoplasm. We now demonstrate that hnRNPA3 also binds to the antisense repeat RNA. Both DPR production and deposition from sense and antisense RNA repeats are increased upon hnRNPA3 reduction. All DPRs induced DNA double strand breaks (DSB), which was further enhanced upon reduction of hnRNPA3. Poly-glycine–arginine and poly-proline-arginine increased foci formed by phosphorylated Ataxia Telangiectasia Mutated (pATM), a major sensor of DSBs, whereas poly-glycine–alanine (poly-GA) evoked a reduction of pATM foci. In dentate gyri of C9orf72 patients, lower nuclear hnRNPA3 levels were associated with increased DNA damage. Moreover, enhanced poly-GA deposition correlated with reduced pATM foci. Since cytoplasmic pATM deposits partially colocalized with poly-GA deposits, these results suggest that poly-GA, the most frequent DPR observed in C9orf72 patients, differentially causes DNA damage and that poly-GA selectively sequesters pATM in the cytoplasm inhibiting its recruitment to sites of DNA damage. Thus, mislocalization of nuclear hnRNPA3 caused by poly-GA leads to increased poly-GA production, which partially depletes pATM, and consequently enhances DSB.

Research field(s)
Health Sciences, Clinical Medicine, Neurology & Neurosurgery

DOI
10.1007/s00401-019-02082-0

Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models

NOMIS Researcher(s)

Published in

January 1, 2020

Upregulation of heat shock proteins (HSPs) is an approach to treatment of neurodegenerative disorders with impaired proteostasis. Many neurons, including motor neurons affected in amyotrophic lateral sclerosis (ALS), are relatively resistant to stress-induced upregulation of HSPs. This study demonstrated that histone deacetylase (HDAC) inhibitors enable the heat shock response in cultured spinal motor neurons, in a stress-dependent manner, and can improve the efficacy of HSP-inducing drugs in murine spinal cord cultures subjected to thermal or proteotoxic stress. The effect of particular HDAC inhibitors differed with the stress paradigm. The HDAC6 (class IIb) inhibitor, tubastatin A, acted as a co-inducer of Hsp70 (HSPA1A) expression with heat shock, but not with proteotoxic stress induced by expression of mutant SOD1 linked to familial ALS. Certain HDAC class I inhibitors (the pan inhibitor, SAHA, or the HDAC1/3 inhibitor, RGFP109) were HSP co-inducers comparable to the hydroxyamine arimoclomol in response to proteotoxic stress, but not thermal stress. Regardless, stress-induced Hsp70 expression could be enhanced by combining an HDAC inhibitor with either arimoclomol or with an HSP90 inhibitor that constitutively induced HSPs. HDAC inhibition failed to induce Hsp70 in motor neurons expressing ALS-linked mutant FUS, in which the heat shock response was suppressed; yet SAHA, RGFP109, and arimoclomol did reduce loss of nuclear FUS, a disease hallmark, and HDAC inhibition rescued the DNA repair response in iPSC-derived motor neurons carrying the FUSP525Lmutation, pointing to multiple mechanisms of neuroprotection by both HDAC inhibiting drugs and arimoclomol.

Research field(s)
Health Sciences, Biomedical Research, Biochemistry & Molecular Biology

DOI
10.1007/s12192-019-01064-1

Wearing your heart on your screen: Investigating congruency-effects in autonomic responses and their role in interoceptive processing during biofeedback

NOMIS Researcher(s)

Published in

January 1, 2020

The experience of one’s embodied sense of self is dependent on the integration of signals originating both from within and outwith one’s body. During the processing and integration of these signals, the bodily self must maintain a fine balance between stability and malleability. Here we investigate the potential role of autonomic responses in interoceptive processing and their contribution to the stability of the bodily self. Using a biofeedback paradigm, we manipulated the congruency of cardiac signals across two hierarchical levels: (i) the low-level congruency between a visual feedback and participant’s own cardiac signal and (ii) the high-level congruency between the participants’ beliefs about the identity of the cardiac feedback and its true identity. We measured the effects of these manipulations on high-frequency heart rate variability (HF-HRV), a selective index of phasic vagal cardiac control. In Experiment 1, HF-HRV was sensitive to low-level congruency, independently of whether participants attempted to regulate or simply attend to the biofeedback. Experiment 2 revealed a higher-level congruency effect, as participants’ prior veridical beliefs increased HF-HRV while when false they decreased HF-HRV. Our results demonstrate that autonomic changes in HF-HRV are sensitive to congruencies across multiple hierarchical levels. Our findings have important theoretical implications for predictive coding models of the self as they pave the way for a more direct way to track the subtle changes in the co-processing of the internal and external milieus.

Research field(s)
Health Sciences, Psychology & Cognitive Sciences, Experimental Psychology

DOI
10.1016/j.cognition.2019.104053

Contributions of place-based social-ecological research to address global sustainability challenges

NOMIS Researcher(s)

Published in

January 1, 2020

null

Research field(s)
Natural Sciences, Earth & Environmental Sciences, Meteorology & Atmospheric Sciences

DOI
10.1017/sus.2020.18

Punishing the individual or the group for norm violation

NOMIS Researcher(s)

Published in

January 1, 2020

Background: It has recently been proposed that a key motivation for joining groups is the protection from consequences of negative behaviours, such as norm violations. Here we empirically test this claim by investigating whether cooperative decisions and the punishment of associated fairness-based norm violations are different in individuals vs. collectives in economic games. Methods: In the ultimatum game, participants made or received offers that they could reject at a cost to their outcome, a form of social punishment. In the dictator game with third-party punishment, participants made offers to a receiver while being observed by a punisher, or could themselves punish unfair offers. Results: Participants made lower offers when making their decision as part of a group as compared to alone. This difference correlated with participants’ overall mean offers: those who were generally less generous were even less so in a group, suggesting that the collective structure was compatible with their intention. Participants were slower when punishing vs not punishing an unfair offer. Importantly here, they were slower when deciding whether to punish or not to punish groups as compared to individuals, only when the offer concerned them directly in second party punishment. Participants thus take more time to punish others, and to make their mind on whether to punish or not when facing a group of proposers. Conclusions: Together, these results show that people behave differently in a group, both in their willingness to share with others and in their punishment of norm violations. This could be explained by the fact that being in a collective structure allows to share responsibility with others, thereby protecting from negative consequences of norm violations.

Research field(s)
Health Sciences, Biomedical Research, Developmental Biology

DOI
10.12688/wellcomeopenres.15474.1

Seeing entities without seeing n-entities

NOMIS Researcher(s)

Published in

January 1, 2020

When seeing a jaguar, we can see all the spots on its mantle without seeing a determinate number, N, of spots on the mantle. How is this visual phenomenon possible? Philosophers have tried to provide a reliable answer to this question, by recruiting evidence from vision science about the way attention works. Here we push this idea forward, by suggesting that an alternative and less complex solution, with respect to the one proposed in the literature, is possible. In particular, we argue that the puzzling visual phenomenon of ‘seeing entities without seeing N-entities’ strictly depends on the specific number of entities we are simultaneously attending to: a problematic scenario concerning this visual process arises only when the number of entities in the visual field exceeds a specific quantity. This depends, as we argue, on the fact that the nature of our visual content is modulated, in this perceptual scenario, by the limited way we can exercise visual attention on the properties of the objects of our perception. Differently from other accounts, our proposal allows us to properly define when and why such a problem arises, and explains why such a situation has traditionally been found to be so puzzling. Our idea is also well motivated by experimental results that so far have not been taken into account in the debate.

Research field(s)
Health Sciences, Psychology & Cognitive Sciences, Experimental Psychology

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease

NOMIS Researcher(s)

Published in

December 9, 2019

Alzheimer’s disease (AD) is currently untreatable, and therapeutic strategies aimed to slow cognitive decline have not yet been successful. Many of these approaches have targeted the amyloid cascade, indicating that novel treatment strategies are required. Recent genome-wide association studies (GWASs) have identified a number of risk factors in genes expressed in microglia, underscoring their therapeutic potential in neurodegeneration. In this review, we discuss how the recently defined functions of these AD risk genes can be targeted therapeutically to modulate microglial cell state and slow the progression of AD. Antibody-mediated stimulation of the triggering receptor of myeloid cells 2 (TREM2) is on the forefront of these candidate therapeutic approaches based on a combination of compelling human genetics and emerging preclinical data. This and other approaches to modify microglial function are a topic of intensive study and provide an opportunity for innovative AD treatments, which may be applied alone or potentially in combination with classical anti-amyloid therapies.

Research field(s)
Health Sciences, Clinical Medicine, Neurology & Neurosurgery

DOI
10.1016/j.neuron.2020.09.029

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

NOMIS Researcher(s)

Published in

December 3, 2019

Metformin is the front-line treatment for type 2 diabetes worldwide. It acts via effects on glucose and lipid metabolism in metabolic tissues, leading to enhanced insulin sensitivity. Despite significant effort, the molecular basis for metformin response remains poorly understood, with a limited number of specific biochemical pathways studied to date. To broaden our understanding of hepatic metformin response, we combine phospho-protein enrichment in tissue from genetically engineered mice with a quantitative proteomics platform to enable the discovery and quantification of basophilic kinase substrates in vivo. We define proteins whose binding to 14-3-3 are acutely regulated by metformin treatment and/or loss of the serine/threonine kinase, LKB1. Inducible binding of 250 proteins following metformin treatment is observed, 44% of which proteins bind in a manner requiring LKB1. Beyond AMPK, metformin activates protein kinase D and MAPKAPK2 in an LKB1-independent manner, revealing additional kinases that may mediate aspects of metformin response. Deeper analysis uncovered substrates of AMPK in endocytosis and calcium homeostasis.

Research field(s)
Health Sciences, Biomedical Research, Developmental Biology

DOI
10.1016/j.celrep.2019.10.117

Electro-optic entanglement source for microwave to telecom quantum state transfer

NOMIS Researcher(s)

Published in

December 1, 2019

We propose an efficient microwave-photonic modulator as a resource for stationary entangled microwave-optical fields and develop the theory for deterministic entanglement generation and quantum state transfer in multi-resonant electro-optic systems. The device is based on a single crystal whispering gallery mode resonator integrated into a 3D-microwave cavity. The specific design relies on a new combination of thin-film technology and conventional machining that is optimized for the lowest dissipation rates in the microwave, optical, and mechanical domains. We extract important device properties from finite-element simulations and predict continuous variable entanglement generation rates on the order of a Mebit/s for optical pump powers of only a few tens of microwatts. We compare the quantum state transfer fidelities of coherent, squeezed, and non-Gaussian cat states for both teleportation and direct conversion protocols under realistic conditions. Combining the unique capabilities of circuit quantum electrodynamics with the resilience of fiber optic communication could facilitate long-distance solid-state qubit networks, new methods for quantum signal synthesis, quantum key distribution, and quantum enhanced detection, as well as more power-efficient classical sensing and modulation.

Research field(s)
Natural Sciences, Physics & Astronomy, General Physics

DOI
10.1038/s41534-019-0220-5

Septins organize endoplasmic reticulum-plasma membrane junctions for STIM1-ORAI1 calcium signalling

NOMIS Researcher(s)

Published in

December 1, 2019

ORAI1 Ca2+ channels in the plasma membrane (PM) are gated by STIM1 at endoplasmic reticulum (ER)-PM junctions to effect store-dependent Ca2+ entry into cells, but little is known about how local STIM-ORAI signalling at junctions is coordinated with overall cellular architecture. Filamentous septins can specify cytoskeletal rearrangements and have been found recently to modulate STIM-ORAI signalling. Here we show by super-resolution imaging of ORAI1, STIM1, and septin 4 in living cells that septins facilitate Ca2+ signalling indirectly. Septin 4 does not colocalize preferentially with ORAI1 in resting or stimulated cells, assemble stably at ER-PM junctions, or specify a boundary that directs or confines ORAI1 to junctions. Rather, ORAI1 is recruited to junctions solely through interaction with STIM proteins, while septins regulate the number of ER-PM junctions and enhance STIM1-ORAI1 interactions within junctions. Thus septins communicate with STIM1 and ORAI1 through protein or lipid intermediaries, and are favorably positioned to coordinate Ca2+ signalling with rearrangements in cellular architecture.

Research field(s)
Health Sciences, Biomedical Research, Developmental Biology

DOI
10.1038/s41598-019-46862-w

Phenotypes and malignancy risk of different FUS mutations in genetic amyotrophic lateral sclerosis

NOMIS Researcher(s)

Published in

December 1, 2019

Objective: Mutations in Fused in Sarcoma (FUS or TLS) are the fourth most prevalent in Western European familial amyotrophic lateral sclerosis (ALS) populations and have been associated with causing both early and very late disease onset. FUS aggregation, DNA repair deficiency, and genomic instability are contributors to the pathophysiology of FUS-ALS, but their clinical significance per se and their influence on the clinical variability have yet to be sufficiently investigated. The aim of this study was to analyze genotype–phenotype correlations and malignancy rates in a newly compiled FUS-ALS cohort. Methods: We cross-sectionally reviewed FUS-ALS patient histories in a multicenter cohort with 36 novel cases and did a meta-analysis of published FUS-ALS cases reporting the largest genotype–phenotype correlation of FUS-ALS. Results: The age of onset (median 39 years, range 11–80) was positively correlated with the disease duration. C-terminal domain mutations were found in 90%. Among all, P525L and truncating/ frameshift mutations most frequently caused juvenile onset, rapid disease progression, and atypical ALS often associated with negative family history while the R521 mutation site was associated with late disease onset and pure spinal phenotype. Malignancies were found in one of 40 patients. Interpretation: We report the largest genotype–phenotype correlation of FUS-ALS, which enables a careful prediction of the clinical course in newly diagnosed patients. In this cohort, FUS-ALS patients did not have an increased risk for malignant diseases.

Research field(s)
Health Sciences, Clinical Medicine, Neurology & Neurosurgery

DOI
10.1002/acn3.50930

Undulating changes in human plasma proteome profiles across the lifespan

NOMIS Researcher(s)

Published in

December 1, 2019

Aging is a predominant risk factor for several chronic diseases that limit healthspan1. Mechanisms of aging are thus increasingly recognized as potential therapeutic targets. Blood from young mice reverses aspects of aging and disease across multiple tissues2–10, which supports a hypothesis that age-related molecular changes in blood could provide new insights into age-related disease biology. We measured 2,925 plasma proteins from 4,263 young adults to nonagenarians (18–95 years old) and developed a new bioinformatics approach that uncovered marked non-linear alterations in the human plasma proteome with age. Waves of changes in the proteome in the fourth, seventh and eighth decades of life reflected distinct biological pathways and revealed differential associations with the genome and proteome of age-related diseases and phenotypic traits. This new approach to the study of aging led to the identification of unexpected signatures and pathways that might offer potential targets for age-related diseases.

Research field(s)
Health Sciences, Clinical Medicine, Immunology

DOI
10.1038/s41591-019-0673-2

Participatory Modeling Updates Expectations forIndividuals and Groups, Catalyzing BehaviorChange and Collective Action inWater-Energy-Food NexusGovernance

NOMIS Researcher(s)

Published in

December 1, 2019

Participatory modeling is a potentially high-impact approach for catalyzing fundamental sustainability transformations. We test if participation in a group system dynamics modeling exercise increases participants’ agency through a novel method to evaluate potential behavioral change using expectation measures. A water-energy-food nexus—a functionally interdependent but underconceptualized system with low consensus and high scientific uncertainty—was mapped, and its evolution simulated by 46 participants in three interventions in a region undergoing hydropower infrastructure development in Northeastern Cambodia. Participants’ system-related expectations were measured before and after the interventions. Our results suggest that participants became significantly more optimistic about their individual agency to increase agricultural and fishing income and, interestingly, less likely to participate in local government development planning procedures. Findings also reveal how some uncertainties for multiple variables were reduced within and across the groups. Such converging expectations suggest that participatory modeling could contribute to making collective solutions and institutionalized agreements more likely. This research contributes to innovation in sustainability because it unpacks some underlying mechanics of how participatory processes can lead to new adaptive capacities, shared perspectives, and collective actions.

Research field(s)
Natural Sciences, Earth & Environmental Sciences, Meteorology & Atmospheric Sciences

DOI
10.1029/2019EF001311

Simultaneous precise editing of multiple genes in human cells

NOMIS Researcher(s)

Published in

November 4, 2019

When double-strand breaks are introduced in a genome by CRISPR they are repaired either by non-homologous end joining (NHEJ), which often results in insertions or deletions (indels), or by homology-directed repair (HDR), which allows precise nucleotide substitutions to be introduced if a donor oligonucleotide is provided. Because NHEJ is more efficient than HDR, the frequency with which precise genome editing can be achieved is so low that simultaneous editing of more than one gene has hitherto not been possible. Here, we introduced a mutation in the human PRKDC gene that eliminates the kinase activity of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This results in an increase in HDR irrespective of cell type and CRISPR enzyme used, sometimes allowing 87% of chromosomes in a population of cells to be precisely edited. It also allows for precise editing of up to four genes simultaneously (8 chromosomes) in the same cell. Transient inhibition of DNA-PKcs by the kinase inhibitor M3814 is similarly able to enhance precise genome editing.

Research field(s)
Health Sciences, Biomedical Research, Developmental Biology

DOI
10.1093/NAR/GKZ669

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

NOMIS Researcher(s)

Published in

November 1, 2019

We identified a PSEN1 (presenilin 1) mutation carrier from the world’s largest autosomal dominant Alzheimer’s disease kindred, who did not develop mild cognitive impairment until her seventies, three decades after the expected age of clinical onset. The individual had two copies of the APOE3 Christchurch (R136S) mutation, unusually high brain amyloid levels and limited tau and neurodegenerative measurements. Our findings have implications for the role of APOE in the pathogenesis, treatment and prevention of Alzheimer’s disease.

Research field(s)
Health Sciences, Clinical Medicine, Immunology

DOI
10.1038/s41591-019-0611-3

Improved applicability and robustness of fast cryo-electron tomography data acquisition

NOMIS Researcher(s)

Published in

November 1, 2019

The power of cryo-electron tomography (cryoET) lies in its capability to characterize macromolecules in their cellular context. Structure determination by cryoET, however, is time-consuming compared to single particle approaches. A recent study reported significant acceleration of data acquisition by a fast-incremental single-exposure (FISE) tilt series scheme. Here we improved the method and evaluated its efficiency and performance. We show that (1) FISE combined with the latest generation of direct electron detectors speeds up collection considerably, (2) previous generation (pre-2017) double-tilt axis Titan Krios holders are also suitable for FISE data acquisition, (3) x, y and z-specimen shifts can be compensated for, and (4) FISE tilt series data can generate averages of sub-nanometer resolution. These advances will allow for a widespread adoption of cryoET for high-throughput in situ studies and high-resolution structure determination across different biological research disciplines.

Research field(s)
Health Sciences, Biomedical Research, Biophysics

DOI
10.1016/j.jsb.2019.08.006

Self-serving incentives impair collective decisions by increasing conformity

NOMIS Researcher(s)

Published in

November 1, 2019

The average judgment of large numbers of people has been found to be consistently better than the best individual response. But what motivates individuals when they make collective decisions? While it is a popular belief that individual incentives promote out-of-the-box thinking and diverse solutions, the exact role of motivation and reward in collective intelligence remains unclear. Here we examined collective intelligence in an interactive group estimation task where participants were rewarded for their individual or group’s performance. In addition to examining individual versus collective incentive structures, we controlled whether participants could see social information about the others’ responses. We found that knowledge about others’ responses reduced the wisdom of the crowd and, crucially, this effect depended on how people were rewarded. When rewarded for the accuracy of their individual responses, participants converged to the group mean, increasing social conformity, reducing diversity and thereby diminishing their group wisdom. When rewarded for their collective performance, diversity of opinions and the group wisdom increased. We conclude that the intuitive association between individual incentives and individualist opinion needs revising.

Research field(s)
Applied Sciences, Information & Communication Technologies, Artificial Intelligence & Image Processing

DOI
10.1371/journal.pone.0224725

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