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The 2024 NOMIS & Science Young Explorer Award was presented to three exceptional young researchers — Jasmine Kwasa, Jason Griffin and T. Christina Zhao — for their bold, cross-disciplinary approaches at a […]

Filling an important gap in design history, NOMIS researcher Anna Myjak-Pycia examines how domestic space was conceived by the US home economics movement in the first half of the 20th […]

NOMIS Awardee Anthony Hyman and collaborators from research institutions in Germany and the US have uncovered how the protein TDP-43 transforms into the solidified condensates that create pathological aggregates seen […]

The observation of Liquid-Liquid Phase Separation (LLPS) in biological cells has dramatically shifted the paradigm that soluble proteins are uniformly dispersed in the cytoplasm or nucleoplasm. The LLPS region is […]

NOMIS Awardee Anthony Hyman and fellow scientists have discovered a small molecule that can prevent the formation of pathological stress granules — protein-rich condensates associated with cellular stress and ALS. […]

Amid the race to develop and market practical quantum computers, NOMIS researcher Georgios Katsaros and his group at the Institute of Science and Technology Austria (ISTA) pay particular attention to […]

Cytosolic aggregation of the nuclear protein TAR DNA-binding protein 43 (TDP-43) is associated with many neurodegenerative diseases, but the triggers for TDP-43 aggregation are still debated. Here, we demonstrate that […]

The ability to robustly predict guide RNA (gRNA) activity is a long-standing goal for CRISPR applications, as it would reduce the need to pre-screen gRNAs. Quantification of formation of short […]

Using the gene scissors CRISPR and stem cells, NOMIS researcher Marc-David Ruepp, together with collaborators at the UK Dementia Research Institute (UK DRI) at King’s College London and Stockholm University, […]

Mutations in FUS and TARDBP cause amyotrophic lateral sclerosis (ALS), but the precise mechanisms of selective motor neuron degeneration remain unresolved. To address if pathomechanisms are shared across mutations and […]

NOMIS Awardee Elena Conti has been awarded the Jung Prize for Medicine 2025 for her seminal contributions to RNA metabolism. The prize is awarded by the Jung Foundation for Science […]

Neurodegenerative diseases, such as amyotrophic lateral sclerosis, are often associated with mutations in stress granule proteins. Aberrant stress granule condensate formation is associated with disease, making it a potential target […]

NOMIS Awardee Elena Conti has been elected to the National Academy of Sciences (NAS) in recognition of her distinguished contributions to original research. The NAS envisions “a nation and world […]

“How can we convey the urgency of the [climate] crisis when its impacts appear so subtle?” NOMIS researcher Tom Griffiths and scientists at Princeton University, UCLA and Carnegie Mellon University […]

Hole spin qubits are emerging as the workhorse of semiconducting quantum processors because of their large spin-orbit interaction, enabling fast, low-power, all-electric operations. However, this interaction also causes non-uniformities, resulting […]

NOMIS Awardee Anne Brunet has been elected to the American Academy of Arts and Sciences in the area of Cellular and Developmental Biology. Academy members include those who discover and […]

For much of the global population, climate change appears as a slow, gradual shift in daily weather. This leads many to perceive its impacts as minor and results in apathy […]

Polyglutamine (polyQ) expansion is associated with pathogenic protein aggregation in neurodegenerative disorders. However, long polyQ tracts are also found in many transcription factors (TFs), such as FOXP2, a TF implicated […]

NOMIS Professor of Genome Biology Jacob Corn and fellow researchers at ETH Zurich have unravelled the complex network that cells use to repair their genetic material. By examining thousands upon […]

The DNA damage response (DDR) is a multifaceted network of pathways that preserves genome stability1,2. Unravelling the complementary interplay between these pathways remains a challenge3,4. Here we used CRISPR interference (CRISPRi) screening […]