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Understanding and targeting Alzheimer’s disease (2019)

May 5, 2019 - May 8, 2019

Dear NOMIS friends and partners,

We would like to inform you of an upcoming conference Understanding and targeting Alzheimer’s disease (2019) which will bring together an outstanding assembly of some of the very best scientists and researchers in Neuroscience.

Christian Haass NOMIS Board Member and Brain Prize winner acting as Co-Chair of the event, and Adriano Aguzzi, 2019 NOMIS Distinguished Scientist and Scholar Awardee as a key speaker will be amongst participants.

Dementia poses one of the largest health and economic problems in the world with over 50 million people worldwide living with dementia, no disease modifying treatments available, and numbers set to dramatically increase as our population ages. Neuroscience research has the real potential to change this bleak future and develop effective ways to prevent or treat the diseases that cause dementia.

Microglia P2Y12 adult cortex, Photo credits: Lasse Dissing-Olesen, Stevens Lab

Three of our current grand challenges towards this goal are to understand why certain brain regions are susceptible to the accumulation of pathology and neurodegeneration early in Alzheimer’s disease and related dementias, how pathologies then spread from these vulnerable regions to damage the rest of the brain, and finally how risk factors like ApoE modulate disease progression.

In this meeting, we will address the best way to move forward as a field in addressing these knowledge gaps with an emphasis on the emerging data in the field implicating non-neuronal contributors to disease risk and regional vulnerability.  The latest clinical trials and the requirement of biomarkers for early risk assessment will be discussed on the background of our understanding of disease mechanisms.  The meeting will end with a podiums discussion on the pros and cons of the amyloid cascade hypothesis.

More information can be found here.