Tony Wyss-Coray, professor of neurology and neurological sciences at Stanford University, California, investigates the role of immune responses in brain aging and neurodegeneration with a focus on cognitive decline and Alzheimer’s disease. His most recent studies have shown that circulatory factors can modulate neurogenesis, neuroimmunity and cognitive function in mice and that blood-derived factors from young mice or humans can rejuvenate the aging mouse brain. The Wyss-Coray lab is now trying to understand the molecular basis of this systemic communication with the brain by employing a combination of omics approaches and through the development of bioorthogonal tools for the in vivo labeling of proteins.
The NOMIS Distinguished Scientist Award is enabling Wyss-Coray and his team to test the hypothesis that circulatory factors that regulate aging can be identified and used to rejuvenate aged and possibly degenerated brains. His lab will use mass spectrometry and proteomic technologies in combination with a new short-lived fish model — the African turquoise killifish, which has been established as the shortest-lived vertebrate aging model by Anne Brunet, professor of genetics at Stanford University and one of the partners of this project — and unique human clinical material. The project seeks to advance the understanding of the basic biology of aging.
In an interview with NOMIS, we asked Wyss-Coray about what drove him to become a scientist and the challenges insight-driven research in his field is facing. Read the complete interview.
Tony Wyss-Coray received a PhD in immunology at the University of Bern, Switzerland, in 1992. He spent his postdoctoral years at the Scripps Research Institute in California and was appointed professor for the Department of Neurology and Neurological Sciences at Stanford University in 2011.
For more information about Tony Wyss-Coray and his research please see his faculty profile.